Yes, phentermine can cause constipation. Many users report changes in their digestive system, particularly experiencing difficulty in passing stools. While this is not a universal side effect, it is common enough to warrant attention.

Phentermine is a prescription medication primarily used for weight loss. It acts as an appetite suppressant, helping individuals reduce their food intake. As with any medication, phentermine can cause various side effects, and one common issue that many users face is constipation.
What is Phentermine?
Phentermine is a stimulant that affects the brain to help suppress hunger. It is often prescribed as a short-term solution for individuals who are obese or overweight, especially when combined with a healthy diet and regular exercise.
Phentermine works by increasing the release of neurotransmitters such as norepinephrine, serotonin, and dopamine, which can reduce hunger and increase feelings of fullness. While effective for weight loss, phentermine side effects in females can vary.
Why Does Phentermine Cause Constipation?
There are several potential reasons why phentermine causes constipation:
- Dehydration: Phentermine has a stimulant effect on the body, which may lead to dehydration. Dehydration can make the stool harder and more difficult to pass.
- Reduced appetite: Since phentermine suppresses hunger, individuals may consume less fiber-rich food, which is essential for healthy bowel movements.
- Changes in metabolism: Phentermine can speed up the body’s metabolic rate, which may affect the digestive system’s ability to function properly.
- Increased stress: Weight loss medications can cause stress or anxiety, which may further disrupt bowel function.
Phentermine Side Effects in Females
While both males and females can experience phentermine side effects, women may face certain unique challenges. Apart from constipation, common side effects in females include:
- Dry mouth
- Insomnia
- Headaches
- Dizziness
- Elevated heart rate
It’s important to note that long-term use of phentermine can exacerbate side effects. Long-term phentermine side effects in females may include changes in menstrual cycles, mood swings, or dependency on the drug.
How Common Is Constipation with Phentermine?
While constipation while taking phentermine is not guaranteed, it is a fairly common side effect. In clinical studies, about 10-20% of users report experiencing gastrointestinal issues, including constipation. The severity of this side effect can vary based on individual factors such as diet, hydration, and activity level.
Symptoms of Constipation
If you’re experiencing constipation while taking phentermine, you might notice the following symptoms:
- Infrequent bowel movements (less than three times a week)
- Hard or lumpy stools
- Straining or discomfort during bowel movements
- Abdominal bloating or pain
If these symptoms persist, it’s important to speak with a healthcare provider.
What Can I Take for Constipation While Taking Phentermine?
If you are struggling with constipation while taking phentermine, there are several remedies you can try to alleviate the condition.
1. Increase Fluid Intake
Dehydration is a common cause of constipation, so drinking more water throughout the day can help soften stools and make them easier to pass.
2. Eat High-Fiber Foods
Fiber plays a crucial role in digestion. Including more fiber-rich foods in your diet, such as fruits, vegetables, whole grains, and legumes, can help regulate bowel movements.
3. Exercise Regularly
Physical activity can stimulate the digestive system and help prevent constipation. Aim for at least 30 minutes of moderate exercise most days of the week.
4. Over-the-Counter Laxatives
If dietary changes and hydration don’t resolve the issue, you might consider using over-the-counter (OTC) laxatives. However, these should only be used under the guidance of a healthcare professional.
5. Fiber Supplements
If you have trouble getting enough fiber from food, fiber supplements can be an effective way to help manage constipation.
6. Probiotics
Probiotics can help balance gut bacteria, which may improve digestive function and alleviate constipation.
Long-Term Phentermine Side Effects in Females

While phentermine side effects in females are often temporary, long-term use can have more serious implications. Women using phentermine for extended periods may experience:
- Dependency: Phentermine is a stimulant, and prolonged use can lead to dependence, both physically and psychologically.
- Hormonal Disruptions: There are reports of hormonal changes, including irregular periods or changes in libido.
- Cardiovascular Issues: Long-term use of phentermine can increase the risk of high blood pressure, heart palpitations, and other heart-related issues.
- Mental Health Effects: Prolonged use may lead to mood swings, irritability, or even depression.
It’s important to use phentermine under a doctor’s supervision, especially for long-term use. Regular check-ups will help monitor any developing side effects.
Common Side Effects of Phentermine
Side Effect | Frequency | Severity |
---|---|---|
Constipation | Common | Moderate |
Dry Mouth | Common | Moderate |
Insomnia | Common | Severe |
Increased Heart Rate | Less Common | Severe |
Headaches | Common | Moderate |
Dizziness | Less Common | Mild |
Anxiety | Less Common | Moderate |
Remedies for Constipation While Taking Phentermine
Remedy | Effectiveness | Ease of Use |
---|---|---|
Increase Fluid Intake | Effective | Easy |
High-Fiber Foods | Effective | Moderate |
Regular Exercise | Effective | Moderate |
OTC Laxatives | Effective | Easy |
Fiber Supplements | Effective | Easy |
Long-Term Phentermine Side Effects in Females
Side Effect | Frequency | Severity |
---|---|---|
Hormonal Disruptions | Less Common | Moderate |
Heart Palpitations | Less Common | Severe |
Dependency | Less Common | Severe |
Changes in Libido | Less Common | Mild |
Weight Regain | Common | Severe |
Anxiety | Less Common | Moderate |
Irregular Periods | Less Common | Mild |
Phentermine Alternatives for Weight Loss
Medication | Effectiveness | Side Effects |
---|---|---|
Orlistat | Moderate | Gas, Diarrhea |
Buproprion/Naltrexone | Effective | Insomnia, Nausea |
Liraglutide | Effective | Nausea, Vomiting |
Diethylpropion | Moderate | Dizziness, Insomnia |
Lorcaserin | Moderate | Headache, Dizziness |
When to see your healthcare provider

If you’re experiencing constipation as a side effect of phentermine, it’s important to monitor the severity and duration of the symptoms. Constipation can be a common side effect of phentermine, but if it’s causing discomfort or becoming severe, you should consider reaching out to your healthcare provider. Here are some signs that it’s time to consult your provider:
- Severe or persistent constipation: If the constipation lasts for more than a few days or becomes particularly painful, it may be worth seeking advice from your healthcare provider.
- Inability to relieve constipation: If you’re having difficulty relieving constipation despite trying over-the-counter remedies like fiber supplements, stool softeners, or increasing your fluid intake, you might need professional guidance.
- Abdominal pain or bloating: If you’re experiencing significant bloating, cramping, or discomfort along with constipation, it could signal that the issue is more than just a side effect and may require treatment.
- Blood in stools: If you notice blood in your stool or rectal bleeding, it’s important to consult your healthcare provider immediately.
- Other side effects: If you’re experiencing other bothersome side effects of phentermine (such as dizziness, trouble sleeping, or rapid heart rate) in addition to constipation, these may indicate that the medication isn’t right for you, and your provider can suggest alternatives.
- Changes in bowel movements: If you notice any other changes in your bowel habits, like excessive straining or feeling that you haven’t fully emptied your bowels, it’s worth speaking with your healthcare provider.
Your healthcare provider can help you determine if phentermine is the cause of your constipation, recommend ways to manage it (like adjusting the dose or suggesting other medications), or explore alternative treatments for your weight management goals.
Conclusion
Phentermine causes constipation in some individuals, and this is a side effect that can disrupt daily life. However, with the right strategies and dietary changes, constipation can often be managed. If you experience severe or persistent constipation, it’s crucial to consult a healthcare provider for alternative treatments or adjustments to your phentermine dosage.
While long-term phentermine side effects in females can include more serious conditions such as hormonal disruptions or cardiovascular issues, using phentermine under the guidance of a medical professional can help mitigate risks. Always be mindful of your body’s responses and prioritize your overall health when using any weight-loss medication.